منابع مشابه
Silent, but deadly--eliminating reservoirs of latent HIV.
HIV treatment with highly active anti-retroviral therapy cannot eliminate latent reservoirs of HIV. In a recent paper, Root and Hamer describe a novel targeting mechanism for killing HIV-infected cells. They show that 5-helix (a gp41-binding protein) fused to a Pseudomonas exotoxin fragment can selectively kill cells displaying envelope proteins on their surface from a broad range of HIV strains.
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Ultrasonic hearing is widespread among moths, but very few moth species have been reported to produce ultrasounds for sexual communication. In those that do, the signals are intense and thus well matched for long distance communication. By contrast, males of the Asian corn borer moth (Crambidae) were recently shown to whisper extremely low-intensity ultrasonic courtship songs close to females. ...
متن کامل“Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet
After more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates. In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemother...
متن کاملQuiet and Poised: “Silent” Genes Accumulate Transcription Machinery
Gene activation—the process of waking up a silent gene and transcribing its DNA—requires many coordinated processes: the gene must be exposed to transcription factors, which must then pile onto specialized sequences adjacent to the gene-called enhancer and promoter regions, which then attract RNA polymerase (the enzyme that catalyzes the synthesis of messenger RNA), which can then attach and pr...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/364110a0